Santa Isabel, Chihuahua México was founded in 1668 by Franciscan religious with the name of Santa Isabel de Tarahumares. The community was located on the border between the Franciscan missions in the plateau region and the Jesuits communities which were located in the mountains. Dedicated mostly to agriculture, Santa Isabel was one of the most prosperous communities in the region during the colonial period.
When independence was achieved from Spain, Santa Isabel became the Municipal Seat of the same name on July 19, 1823, and continues to hold this position today. Santa Isabel is a place of interest to Catholics since former Parish priest Pedro de Jesús Maldonado was canonized in 2000, which has made him the only recognized saint from the state of Chihuahua.
Today the town is still dedicated to agricultural activities. It is known for its spas, which are frequented by visitors from the nearby cities of Chihuahua and Cuauhtémoc. It is also famous for the local manufacture of the Germania Ice Popsicles, which people from around the state come to eat when visiting the community.
Santa Isabel is located in the center of Chihuahua State. It sits in a wide agricultural valley at an altitude of 1,620 meters on the level of the sea, next to the Santa Isabel River. Its distance from the state capital in Chihuahua City is 50 kilometers to the Southwest. It is also 50 kilometers east of Cuauhtémoc, so it is considered the middle point of Federal Highway 16 that connects both cities. The Chihuahua to the Pacific Railroad also goes through Santa Isabel, running from Chihuahua City to the town of San Andrés and then to Cuauhtémoc, through the Rocky Mountains, ending at the coast in the State of Sinaloa.

According to the Population and Housing Count conducted in 2005 by the National Institute of Statistics and Geography, Santa Isabel has a population of 1,412 inhabitants, of whom 699 are men and 713 are women (WP. Accessed 11-12-18).